Siddharth Jain, Paul R. Rosenbaum, Joseph G. Reiter, Alexander S. Hill, David A. Wolk, Sean Hashemi, Lee A. Fleisher, Roderic Eckenhoff, Jeffrey H. Silber (2022), Risk of Parkinson’s disease after anaesthesia and surgery, British Journal of Anaesthesia , 3.
Abstract: We previously examined the association between the exposure of surgery and anaesthesia for appendicitis and the subsequent development of Alzheimer's disease and related dementias (ADRD).1,2 We chose to focus on appendicectomy because appendicitis appears to occur fairly randomly (acting as a natural experiment), and its sequelae are generally not long term, unlike other procedures possibly needed as a result of underlying illnesses that may affect long-term outcomes. Literature has suggested that there are common pathways of neurodegeneration in Parkinson's disease (PD) and ADRD.3–5 We used the same cohort of patients who received an appendicectomy for appendicitis with similarly matched patients who did not have an appendicectomy, to investigate an association between exposure to surgery and anaesthesia and PD.
Rachel R. Kelz, Morgan M. Sellers, Bijan A. Niknam, James E. Sharpe, Paul R. Rosenbaum, Alexander S. Hill, Hong Zhou, Lauren L. Hochman, Karl Y. Bilimoria, Kamal Itani, Patrick S. Romano, Jeffrey H. Silber (2020), A national comparison of operative outcomes of new and experienced surgeons, Annals of Surgery, 9. 10.1097/SLA.0000000000003388
Rachel R. Kelz, Bijan A. Niknam, Morgan M. Sellers, James E. Sharpe, Paul R. Rosenbaum, Alexander S. Hill, Hong Zhou, Lauren L. Hochman, Karl Y. Bilimoria, Kamal Itani, Patrick S. Romano, Jeffrey H. Silber (2020), Duty hour reform and the outcomes of patients treated by new surgeons, Annals of Surgery, 271 (4), pp. 599-605.
Jeffrey H. Silber, Paul R. Rosenbaum, Bijan A. Niknam, Richard N. Ross, Joseph G. Reiter, Alexander S. Hill, Lauren L. Hochman, Sydney E. Brown, Alexander F. Arriaga, Lee A. Fleisher (2020), Comparing outcomes and costs of medical patients treated at major teaching and non-teaching hospitals: a national matched analysis, Journal of General Internal Medicine, 35 (3), pp. 743-752.
Jeffrey H. Silber, Paul R. Rosenbaum, Bijan A. Niknam, Richard N. Ross, Joseph G. Reiter, Alexander S. Hill, Lauren L. Hochman, Sydney E. Brown, Alexander F. Arriaga, Rachel R. Kelz, Lee A. Fleisher (2020), Comparing outcomes and costs of surgical patients treated at major teaching and nonteaching hospitals: a national matched analysis, Annals of Surgery, 271 (3), pp. 412-421.
Jeffrey H. Silber, Paul R. Rosenbaum, Samuel Pimentel, Shawna Calhoun, Wei Wang, James Sharpe, Joseph Reiter, Shivani Shah, Lauren Hochman, Orit Even-Shoshan (2019), Comparing resource use in medical admissions of children with complex chronic conditions, Medical Care, 57 (8), pp. 615-624.
Jeffrey H. Silber, Lisa M. Bellini, Judy A. Shea, Sanjay V. Desai, David F. Dinges, Mathias Basner, Orit Even-Shoshan, Alexander S. Hill, Lauren L. Hochman, Joel T. Katz, Richard N. Ross, David M. Shade, Dylan Small, Alice L. Sternberg, James Tonascia, Kevin G. Volpp, David A. Asch, for the iCOMPARE Research Group (2019), Patient Safety Outcomes under Flexible and Standard Resident Duty-Hour Rules, New England Journal of Medicine, 380 (), pp. 905-914.
Mathias Basner, David A. Asch, Judy A. Shea, Lisa M. Bellini, Michele Carlin, Adrian J. Ecker, Susan K. Malone, Sanjay V. Desai, Alice L. Sternberg, James Tonascia, David M. Shade, Joel T. Katz, David W. Bates, Orit Even-Shoshan, Jeffrey H. Silber, Dylan Small, Kevin G. Volpp, Christopher G. Mott, Sara Coats, Daniel J. Mollicone, David F. Dinges for the iCOMPARE Research Group (2019), Sleep and Alertness in a Duty-Hour Flexibility Trial in Internal Medicine, New England Journal of Medicine, 380 (), pp. 915-923.
Jeffrey H. Silber, Paul R. Rosenbaum, Richard N. Ross, Joseph G. Reiter, Bijan A. Niknam, Alexander S. Hill, Diana M. Bongiorno, Shivani A. Shah, Lauren L. Hochman, Orit Even-Shoshan, Kevin R. Fox (2018), Disparities in breast cancer survival by socioeconomic status despite Medicare and Medicaid insurance, Milbank Quarterly, 96 (4), pp. 706-754.
Judy A. Shea, Jeffrey H. Silber, Sanjay V. Desai, David F. Dinges, Lisa M. Bellini, James Tonascia, Alice L. Sternberg, Dylan Small, David M. Shade, Joel Thorp Katz, Mathias Basner, Krisda H. Chaiyachati, Orit Even-Shoshan, David Westfall Bates, Kevin G. Volpp, David A. Asch, the iCOMPARE Research Group (2018), Development of the Individualised Comparative Effectiveness of Models Optimizing Patient Safety and Resident Education (iCOMPARE) Trial: a Protocol Summary of a National Cluster-randomised Trial of Resident Duty Hour Policies in Internal Medicine, BMJ Open, 8(9):e021711 ().